PRISM

The PRISM project aims to better understand why some young children suffer from recurrent respiratory tract infections (rRTIs), despite having no identifiable immune deficiency. While current clinical approaches focus mainly on detecting and treating immune deficiencies or infections themselves, PRISM investigates an often-overlooked factor: chronic immune activation.

By analysing both systemic (blood) and mucosal (saliva) inflammatory markers at baseline and during infections, the study explores how immune responses at different levels contribute to susceptibility. This dual focus may reveal new diagnostic insights and open the door to novel treatment strategies, including anti-inflammatory approaches, ultimately improving outcomes for children at risk of long-term respiratory complications.