SALIAC

The SALIAC study investigates the connection between respiratory infections in early childhood and the development of Chronic Obstructive Pulmonary Disease (COPD), specifically the frequent exacerbation phenotype, later in life. Traditionally, COPD was thought to result from smoking and air pollution. However, recent research emphasizes the role of genetics and environmental influences across an individual’s lifespan. Studies have shown that lower respiratory tract infections within the first two years of life are linked to poorer outcomes in adulthood, including reduced lung function.

We hypothesize that recurrent respiratory tract infections during childhood contribute to long-term immune maladaptation, leading to persistent inflammation and an increased risk of COPD, particularly its frequent exacerbation phenotype. To explore this, the SALIAC study aims to analyze immune function by comparing saliva samples from children with recurrent respiratory infections and adults with frequent COPD exacerbations. Using non-invasive saliva sampling, the research seeks to identify shared mucosal immune biomarkers and examine how immune dysregulation in early childhood may predispose individuals to chronic respiratory issues in adulthood.

This collaborative effort between Maastricht UMC+, and Radboud University Medical Center combines expertise across immunology, pulmonology, and pediatric infections. We hope our findings will bridge the gap between early-life health and adult respiratory conditions, ultimately improving long-term patient outcomes.